2GFP

Structure of the Multidrug Transporter EmrD from Escherichia coli

2GFP の概要

• エントリーDOI: 10.2210/pdb2gfp/pdb
• 分子名称: Multidrug resistance protein D (1 entity in total)
• 機能のキーワード: membrane protein; multidrug transporter, membrane protein
• 由来する生物種: Escherichia coli
• 細胞内の位置: Cell inner membrane; Multi-pass membrane protein: P31442
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 80027.80

構造登録者

Yin, Y.,He, X.,Szewczyk, P.,Nguyen, T.,Chang, G. (登録日: 2006-03-22, 公開日: 2006-05-16, 最終更新日: 2024-02-14)

主引用文献

Yin, Y.,He, X.,Szewczyk, P.,Nguyen, T.,Chang, G.
Structure of the multidrug transporter EmrD from Escherichia coli
Science, 312:741-744, 2006

PubMed Abstract: EmrD is a multidrug transporter from the Major Facilitator Superfamily that expels amphipathic compounds across the inner membrane of Escherichia coli. Here, we report the x-ray structure of EmrD determined to a resolution of 3.5 angstroms. The structure reveals an interior that is composed mostly of hydrophobic residues, which is consistent with its role transporting amphipathic molecules. Two long loops extend into the inner leaflet side of the cell membrane. This region can serve to recognize and bind substrate directly from the lipid bilayer. We propose that multisubstrate specificity, binding, and transport are facilitated by these loop regions and the internal cavity.

PubMed: 16675700
DOI: 10.1126/science.1125629

実験手法

X-RAY DIFFRACTION (3.5 Å)