2GDZ

Crystal structure of 15-hydroxyprostaglandin dehydrogenase type1, complexed with NAD+

2GDZ の概要

• エントリーDOI: 10.2210/pdb2gdz/pdb
• 分子名称: NAD+-dependent 15-hydroxyprostaglandin dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (3 entities in total)
• 機能のキーワード: hydroxyprostaglandin, dehydrogenase, structural genomics, short-chain dehydrogenase/reductase, inflammation, structural genomics consortium, sgc, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P15428
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29842.96

構造登録者

Pilka, E.S.,Guo, K.,Kavanagh, K.,Von Delft, F.,Arrowsmith, C.,Weigelt, J.,Edwards, A.,Sundstrom, M.,Oppermann, U.,Structural Genomics Consortium (SGC) (登録日: 2006-03-17, 公開日: 2006-04-04, 最終更新日: 2023-10-25)

• 主引用文献: Niesen, F.H.,Schultz, L.,Jadhav, A.,Bhatia, C.,Guo, K.,Maloney, D.J.,Pilka, E.S.,Wang, M.,Oppermann, U.,Heightman, T.D.,Simeonov, A.; High-Affinity Inhibitors of Human NAD-Dependent 15-Hydroxyprostaglandin Dehydrogenase: Mechanisms of Inhibition and Structure-Activity Relationships.; Plos One, 5:e13719-e13719, 2010; PubMed: 21072165; DOI: 10.1371/journal.pone.0013719

実験手法

X-RAY DIFFRACTION (1.65 Å)