2GAB
Human Transthyretin (TTR) Complexed with Hydroxylated polychlorinated Biphenyl-4-hydroxy-3,3',5,4'-tetrachlorobiphenyl
Summary for 2GAB
Entry DOI | 10.2210/pdb2gab/pdb |
Descriptor | Transthyretin, 3,3',4',5-TETRACHLOROBIPHENYL-4-OL (3 entities in total) |
Functional Keywords | ttr, amyloid, transthyretin, hormone-growth factor complex, hormone/growth factor |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P02766 |
Total number of polymer chains | 2 |
Total formula weight | 28170.69 |
Authors | Palaninathan, S.K.,Smith, C.,Safe, S.H.,Kelly, J.W.,Sacchettini, J.C. (deposition date: 2006-03-08, release date: 2006-03-21, Last modification date: 2023-08-30) |
Primary citation | Purkey, H.E.,Palaninathan, S.K.,Kent, K.C.,Smith, C.,Safe, S.H.,Sacchettini, J.C.,Kelly, J.W. Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity Chem.Biol., 11:1719-1728, 2004 Cited by PubMed: 15610856DOI: 10.1016/j.chembiol.2004.10.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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