2G9C

Modified pyrimidines Specifically bind the purine riboswitch

Summary for 2G9C

Entry DOI	10.2210/pdb2g9c/pdb
Descriptor	guanine riboswitch, ACETATE ION, COBALT HEXAMMINE(III), ... (5 entities in total)
Functional Keywords	mrna, riboswitch, triaminopyrimidine, rna-ligand complex, rna
Total number of polymer chains	1
Total formula weight	23625.34
Authors	Gilbert, S.D.,Mediatore, S.J.,Batey, R.T. (deposition date: 2006-03-06, release date: 2006-11-21, Last modification date: 2024-02-14)
Primary citation	Gilbert, S.D.,Mediatore, S.J.,Batey, R.T. Modified pyrimidines specifically bind the purine riboswitch. J.Am.Chem.Soc., 128:14214-14215, 2006 Cited by PubMed Abstract: The purine riboswitch is a genetic regulatory element found in the 5'-untranslated regions of Gram-positive bacteria that regulates expression of the mRNA specifically in response to either guanine or adenine. We report that the adenine-responsive RNA element is also capable of specifically recognizing pyrimidine compounds bearing modifications at the 6- or 5,6-positions in a fashion similar to that of purine compounds. Using isothermal titration calorimetry and X-ray crystallography, the binding of these compounds is characterized. PubMed: 17076468 DOI: 10.1021/ja063645t PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation