2G9C

Modified pyrimidines Specifically bind the purine riboswitch

2G9C の概要

• エントリーDOI: 10.2210/pdb2g9c/pdb
• 分子名称: guanine riboswitch, ACETATE ION, COBALT HEXAMMINE(III), ... (5 entities in total)
• 機能のキーワード: mrna, riboswitch, triaminopyrimidine, rna-ligand complex, rna
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23625.34

構造登録者

Gilbert, S.D.,Mediatore, S.J.,Batey, R.T. (登録日: 2006-03-06, 公開日: 2006-11-21, 最終更新日: 2024-02-14)

主引用文献

Gilbert, S.D.,Mediatore, S.J.,Batey, R.T.
Modified pyrimidines specifically bind the purine riboswitch.
J.Am.Chem.Soc., 128:14214-14215, 2006

PubMed Abstract: The purine riboswitch is a genetic regulatory element found in the 5'-untranslated regions of Gram-positive bacteria that regulates expression of the mRNA specifically in response to either guanine or adenine. We report that the adenine-responsive RNA element is also capable of specifically recognizing pyrimidine compounds bearing modifications at the 6- or 5,6-positions in a fashion similar to that of purine compounds. Using isothermal titration calorimetry and X-ray crystallography, the binding of these compounds is characterized.

PubMed: 17076468
DOI: 10.1021/ja063645t

実験手法

X-RAY DIFFRACTION (1.7 Å)