2G5U

Human Transthyretin (TTR) Complexed with Hydroxylated polychlorinated Biphenyl-4,4'-dihydroxy-3,3',5,5'-tetrachlorobiphenyl

2G5U の概要

• エントリーDOI: 10.2210/pdb2g5u/pdb
• 分子名称: Transthyretin, 3,5,3',5'-TETRACHLORO-BIPHENYL-4,4'-DIOL (3 entities in total)
• 機能のキーワード: ttr, amyloid, transthyretin, hormone-growth factor complex, hormone/growth factor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P02766
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28202.69

構造登録者

Palaninathan, S.K.,Smith, C.,Safe, S.H.,Kelly, J.W.,Sacchettini, J.C. (登録日: 2006-02-23, 公開日: 2006-03-07, 最終更新日: 2023-08-30)

• 主引用文献: Purkey, H.E.,Palaninathan, S.K.,Kent, K.C.,Smith, C.,Safe, S.H.,Sacchettini, J.C.,Kelly, J.W.; Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity; Chem.Biol., 11:1719-1728, 2004; PubMed: 15610856; DOI: 10.1016/j.chembiol.2004.10.009

実験手法

X-RAY DIFFRACTION (1.8 Å)