2G0G

Structure-based drug design of a novel family of PPAR partial agonists: virtual screening, x-ray crystallography and in vitro/in vivo biological activities

2G0G の概要

• エントリーDOI: 10.2210/pdb2g0g/pdb
• 関連するPDBエントリー: 2G0H
• 分子名称: Peroxisome proliferator-activated receptor gamma, 3-FLUORO-N-[1-(4-FLUOROPHENYL)-3-(2-THIENYL)-1H-PYRAZOL-5-YL]BENZENESULFONAMIDE (3 entities in total)
• 機能のキーワード: ppar, transcription activator
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: P37231
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 62411.49

構造登録者

Lu, I.L.,Peng, Y.H.,Huang, C.F.,Lin, Y.T.,Hsu, J.T.A.,Wu, S.Y. (登録日: 2006-02-13, 公開日: 2006-05-16, 最終更新日: 2023-10-25)

• 主引用文献: Lu, I.L.,Huang, C.F.,Peng, Y.H.,Lin, Y.T.,Hsieh, H.P.,Chen, C.T.,Lien, T.W.,Lee, H.J.,Mahindroo, N.,Prakash, E.,Yueh, A.,Chen, H.Y.,Goparaju, C.M.,Chen, X.,Liao, C.C.,Chao, Y.S.,Hsu, J.T.,Wu, S.Y.; Structure-Based Drug Design of a Novel Family of PPARgamma Partial Agonists: Virtual Screening, X-ray Crystallography, and in Vitro/in Vivo Biological Activities; J.Med.Chem., 49:2703-2712, 2006; PubMed: 16640330; DOI: 10.1021/jm051129s

実験手法

X-RAY DIFFRACTION (2.54 Å)