2G0D

Nisin cyclase

2G0D の概要

• エントリーDOI: 10.2210/pdb2g0d/pdb
• 関連するPDBエントリー: 2GO2
• 分子名称: Nisin biosynthesis protein nisC, ZINC ION (3 entities in total)
• 機能のキーワード: alpha toroid, alpha barrel, biosynthetic protein
• 由来する生物種: Lactococcus lactis subsp. lactis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 46857.91

構造登録者

Nair, S.K. (登録日: 2006-02-12, 公開日: 2006-05-23, 最終更新日: 2024-02-14)

主引用文献

Li, B.,Yu, J.P.J.,Brunzelle, J.S.,Moll, G.N.,Van der Donk, W.A.,Nair, S.K.
Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis
Science, 311:1464-1467, 2006

PubMed Abstract: Nisin is a posttranslationally modified antimicrobial peptide that is widely used as a food preservative. It contains five cyclic thioethers of varying sizes that are installed by a single enzyme, NisC. Reported here are the in vitro reconstitution of the cyclization process and the x-ray crystal structure of the NisC enzyme. The structure reveals similarities in fold and substrate activation with mammalian farnesyl transferases, suggesting that human homologs of NisC posttranslationally modify a cysteine of a protein substrate.

PubMed: 16527981
DOI: 10.1126/science.1121422

実験手法

X-RAY DIFFRACTION (2.21 Å)