2G01

Pyrazoloquinolones as Novel, Selective JNK1 inhibitors

Summary for 2G01

• Entry DOI: 10.2210/pdb2g01/pdb
• Descriptor: Mitogen-activated protein kinase 8, C-jun-amino-terminal kinase-interacting protein 1, SULFATE ION, ... (4 entities in total)
• Functional Keywords: jnk1, c-jun n-terminal kinase, protein kinase jnk1 inhibitors, transferase
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm : P45983 Q9UQF2
• Total number of polymer chains: 4
• Total formula weight: 89441.95

Authors

Abad-Zapatero, C. (deposition date: 2006-02-10, release date: 2006-04-18, Last modification date: 2023-08-30)

• Primary citation: Liu, M.,Xin, Z.,Clampit, J.E.,Wang, S.,Gum, R.J.,Haasch, D.L.,Trevillyan, J.M.,Abad-Zapatero, C.,Fry, E.H.,Sham, H.L.,Liu, G.; Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors.; Bioorg.Med.Chem.Lett., 16:2590-2594, 2006; PubMed: 16527482; DOI: 10.1016/j.bmcl.2006.02.046

Experimental method

X-RAY DIFFRACTION (3.5 Å)