2FZK

The Structure of Wild-Type E. Coli Aspartate Transcarbamoylase in Complex with Novel T State Inhibitors at 2.50 Resolution

Summary for 2FZK

Entry DOI	10.2210/pdb2fzk/pdb
Related	1ZA1 1ZA2 2FZC 2FZG
Descriptor	Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, 3,5-BIS[(PHOSPHONOACETYL)AMINO]BENZOIC ACID, ... (6 entities in total)
Functional Keywords	inhibitors, allosteric transition, xray structures, transferase
Biological source	Escherichia coli More
Total number of polymer chains	4
Total formula weight	104850.96
Authors	Heng, S.,Stieglitz, K.A.,Eldo, J.,Xia, J.,Cardia, J.P.,Kantrowitz, E.R. (deposition date: 2006-02-09, release date: 2006-08-29, Last modification date: 2023-08-30)
Primary citation	Heng, S.,Stieglitz, K.A.,Eldo, J.,Xia, J.,Cardia, J.P.,Kantrowitz, E.R. T-state Inhibitors of E. coli Aspartate Transcarbamoylase that Prevent the Allosteric Transition. Biochemistry, 45:10062-10071, 2006 Cited by PubMed: 16906764 DOI: 10.1021/bi0601095 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation