2FZI
New Insights into DHFR Interactions: Analysis of Pneumocystis carinii and Mouse DHFR Complexes with NADPH and Two Highly Potent Trimethoprim Derivatives
2FZI の概要
エントリーDOI | 10.2210/pdb2fzi/pdb |
関連するPDBエントリー | 1U70 2cd2 2FZH 2FZJ |
分子名称 | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2,4-DIAMINO-5-[3',4'-DIMETHOXY-5'-(5-CARBOXYL-1-PENTYNYL)]BENZYL PYRIMIDINE, ... (4 entities in total) |
機能のキーワード | dihydrofolate reductase, trimethoprim derivatives, ring stacking interactions, oxidoreductase |
由来する生物種 | Pneumocystis carinii |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 25034.36 |
構造登録者 | |
主引用文献 | Cody, V.,Pace, J.,Chisum, K.,Rosowsky, A. New insights into DHFR interactions: analysis of Pneumocystis carinii and mouse DHFR complexes with NADPH and two highly potent 5-(omega-carboxy(alkyloxy) trimethoprim derivatives reveals conformational correlations with activity and novel parallel ring stacking interactions. Proteins, 65:959-969, 2006 Cited by PubMed: 17019704DOI: 10.1002/prot.21131 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.6 Å) |
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