2FZH

New Insights into Dihydrofolate Reductase Interactions: Analysis of Pneumocystis carinii and Mouse DHFR Complexes with NADPH and Two Highly Potent Trimethoprim Derivatives

2FZH の概要

• エントリーDOI: 10.2210/pdb2fzh/pdb
• 関連するPDBエントリー: 1U7O 2CD2 2FZI 2FZJ
• 分子名称: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2,4-DIAMINO-5-[2-METHOXY-5-(4-CARBOXYBUTYLOXY)BENZYL]PYRIMIDINE, ... (4 entities in total)
• 機能のキーワード: dihydrofolate reductase, trimethoprim derivatives, ring stacking interactions, oxidoreductase
• 由来する生物種: Pneumocystis carinii
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25010.34

構造登録者

Cody, V.,Pace, J.,Chisum, K.,Rosowsky, A. (登録日: 2006-02-09, 公開日: 2006-12-26, 最終更新日: 2023-08-30)

• 主引用文献: Cody, V.,Pace, J.,Chisum, K.,Rosowsky, A.; New insights into DHFR interactions: analysis of Pneumocystis carinii and mouse DHFR complexes with NADPH and two highly potent 5-(omega-carboxy(alkyloxy) trimethoprim derivatives reveals conformational correlations with activity and novel parallel ring stacking interactions.; Proteins, 65:959-969, 2006; PubMed: 17019704; DOI: 10.1002/prot.21131

実験手法

X-RAY DIFFRACTION (2.1 Å)