2FY5

Structures of ligand bound human choline acetyltransferase provide insight into regulation of acetylcholine synthesis

2FY5 の概要

• エントリーDOI: 10.2210/pdb2fy5/pdb
• 関連するPDBエントリー: 2fy2 2fy3 2fy4
• 分子名称: Choline O-acetyltransferase, [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL (3R)-3-HYDROXY-2,2-DIMETHYL-4-OXO-4-{[3-OXO-3-({2-[(2-OXOPROPYL)THIO]ETHYL}AMINO)PROPYL]AMINO}BUTYL DIHYDROGEN DIPHOSPHATE (3 entities in total)
• 機能のキーワード: two domain, alpha-beta protein, transferase, s-2-(oxopropyl)-coenzyme a
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 68936.95

構造登録者

Kim, A.R.,Rylett, R.J.,Shilton, B.H. (登録日: 2006-02-07, 公開日: 2006-12-12, 最終更新日: 2023-08-30)

• 主引用文献: Kim, A.R.,Rylett, R.J.,Shilton, B.H.; Substrate binding and catalytic mechanism of human choline acetyltransferase.; Biochemistry, 45:14621-14631, 2006; PubMed: 17144655; DOI: 10.1021/bi061536l

実験手法

X-RAY DIFFRACTION (2.6 Å)