2FVD

Cyclin Dependent Kinase 2 (CDK2) with diaminopyrimidine inhibitor

2FVD の概要

• エントリーDOI: 10.2210/pdb2fvd/pdb
• 分子名称: Cell division protein kinase 2, (4-AMINO-2-{[1-(METHYLSULFONYL)PIPERIDIN-4-YL]AMINO}PYRIMIDIN-5-YL)(2,3-DIFLUORO-6-METHOXYPHENYL)METHANONE (3 entities in total)
• 機能のキーワード: cdk2 ligand, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34417.94

構造登録者

Crowther, R.L.,Lukacs, C.M.,Kammlott, R.U. (登録日: 2006-01-30, 公開日: 2006-10-10, 最終更新日: 2024-02-14)

• 主引用文献: Chu, X.J.,DePinto, W.,Bartkovitz, D.,So, S.S.,Vu, B.T.,Packman, K.,Lukacs, C.,Ding, Q.,Jiang, N.,Wang, K.,Goelzer, P.,Yin, X.,Smith, M.A.,Higgins, B.X.,Chen, Y.,Xiang, Q.,Moliterni, J.,Kaplan, G.,Graves, B.,Lovey, A.,Fotouhi, N.; Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), a potent and selective cyclin-dependent kinase inhibitor with significant in vivo antitumor activity.; J.Med.Chem., 49:6549-6560, 2006; PubMed: 17064073; DOI: 10.1021/jm0606138

実験手法

X-RAY DIFFRACTION (1.85 Å)