2FU2

Crystal structure of protein SPy2152 from Streptococcus pyogenes

Summary for 2FU2

• Entry DOI: 10.2210/pdb2fu2/pdb
• Descriptor: Hypothetical protein SPy2152 (2 entities in total)
• Functional Keywords: structural genomics, psi, protein structure initiative, midwest center for structural genomics, mcsg, unknown function
• Biological source: Streptococcus pyogenes
• Total number of polymer chains: 1
• Total formula weight: 11468.67

Authors

Chang, C.,Cymborowski, M.,Otwinowski, Z.,Minor, W.,Lezondra, L.-E.,Clancy, S.,Joachimiak, A.,Midwest Center for Structural Genomics (MCSG) (deposition date: 2006-01-25, release date: 2006-03-07, Last modification date: 2024-11-06)

Primary citation

Chang, C.,Coggill, P.,Bateman, A.,Finn, R.D.,Cymborowski, M.,Otwinowski, Z.,Minor, W.,Volkart, L.,Joachimiak, A.
The structure of pyogenecin immunity protein, a novel bacteriocin-like immunity protein from Streptococcus pyogenes.
Bmc Struct.Biol., 9:75-75, 2009

PubMed Abstract: Many Gram-positive lactic acid bacteria (LAB) produce anti-bacterial peptides and small proteins called bacteriocins, which enable them to compete against other bacteria in the environment. These peptides fall structurally into three different classes, I, II, III, with class IIa being pediocin-like single entities and class IIb being two-peptide bacteriocins. Self-protective cognate immunity proteins are usually co-transcribed with these toxins. Several examples of cognates for IIa have already been solved structurally. Streptococcus pyogenes, closely related to LAB, is one of the most common human pathogens, so knowledge of how it competes against other LAB species is likely to prove invaluable.

PubMed: 20017931
DOI: 10.1186/1472-6807-9-75

Experimental method

X-RAY DIFFRACTION (2.15 Å)