2FSE

Crystallographic structure of a rheumatoid arthritis MHC susceptibility allele, HLA-DR1 (DRB1*0101), complexed with the immunodominant determinant of human type II collagen

2FSE の概要

• エントリーDOI: 10.2210/pdb2fse/pdb
• 分子名称: H-2 class II histocompatibility antigen, E-K alpha chain, HLA class II histocompatibility antigen, DRB1-1 beta chain, Collagen alpha-1(II), ... (4 entities in total)
• 機能のキーワード: rheumatoid arthritis, hla-dr1, collagen type ii, antigen presentation, immune system, structural protein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein: P01903 P04229; Secreted, extracellular space, extracellular matrix : P02458
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 87962.28

構造登録者

Ivey, R.A.,Rosloniec, E.F.,Whittington, K.B.,Kang, A.H.,Park, H.W. (登録日: 2006-01-22, 公開日: 2006-09-19, 最終更新日: 2017-10-18)

• 主引用文献: Rosloniec, E.F.,Ivey, R.A.,Whittington, K.B.,Kang, A.H.,Park, H.W.; Crystallographic Structure of a Rheumatoid Arthritis MHC Susceptibility Allele, HLA-DR1 (DRB1*0101), Complexed with the Immunodominant Determinant of Human Type II Collagen.; J.Immunol., 177:3884-3892, 2006; PubMed: 16951351

実験手法

X-RAY DIFFRACTION (3.1 Å)