2FQQ
Crystal structure of human caspase-1 (Cys285->Ala, Cys362->Ala, Cys364->Ala, Cys397->Ala) in complex with 1-methyl-3-trifluoromethyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (2-mercapto-ethyl)-amide
Summary for 2FQQ
Entry DOI | 10.2210/pdb2fqq/pdb |
Related | 1sc1 1sc3 1sc4 2FQR 2FQS 2FQU 2FQV |
Descriptor | Caspase-1, 1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE, ... (4 entities in total) |
Functional Keywords | caspase, allosteric inhibitor, hydrolase |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: P29466 P29466 |
Total number of polymer chains | 2 |
Total formula weight | 30309.66 |
Authors | Scheer, J.M.,Wells, J.A.,Romanowski, M.J. (deposition date: 2006-01-18, release date: 2006-05-16, Last modification date: 2023-08-30) |
Primary citation | Scheer, J.M.,Romanowski, M.J.,Wells, J.A. A common allosteric site and mechanism in caspases Proc.Natl.Acad.Sci.USA, 103:7595-7600, 2006 Cited by PubMed: 16682620DOI: 10.1073/pnas.0602571103 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
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