2FNT

Crystal structure of a drug-resistant (V82A) inactive (D25N) HIV-1 protease complexed with AP2V variant of HIV-1 NC-p1 substrate.

2FNT の概要

関連するPDBエントリー1TSQ 2FNS
分子名称protease, NC-p1 substrate PEPTIDE, ACETATE ION, ... (5 entities in total)
機能のキーワードstructural intermediate, substrate recognition, hiv-1 protease, nc-p1 substrate, drug resistance, flap conformation, hydrolase
由来する生物種Human immunodeficiency virus 1
詳細
ポリマー鎖数3
分子量合計23482.8
構造登録者
Prabu-Jeyabaln, M.,Nalivaika, E.A.,Schiffer, C.A. (登録日: 2006-01-11, 公開日: 2006-09-05, 最終更新日: 2017-10-18)
主引用文献
Prabu-Jeyabalan, M.,Nalivaika, E.A.,Romano, K.,Schiffer, C.A.
Mechanism of substrate recognition by drug-resistant human immunodeficiency virus type 1 protease variants revealed by a novel structural intermediate.
J.Virol., 80:3607-3616, 2006
PubMed: 16537628 (主引用文献が同じPDBエントリー)
DOI: 10.1128/JVI.80.7.3607-3616.2006
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (1.44 Å)
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構造検証レポート

ClashscoreRamachandran outliersSidechain outliers102.0%1.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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