2FNS
Crystal structure of wild-type inactive (D25N) HIV-1 protease complexed with wild-type HIV-1 NC-p1 substrate.
Summary for 2FNS
| Entry DOI | 10.2210/pdb2fns/pdb |
| Related | 1TSU 2FNT |
| Descriptor | Protease, NC-P1 SUBSTRATE PEPTIDE, ACETATE ION, ... (5 entities in total) |
| Functional Keywords | structural intermediate, substrate recognition, hiv-1 protease, nc-p1 substrate, drug resistance, flap conformation, hydrolase |
| Biological source | Human immunodeficiency virus 1 More |
| Total number of polymer chains | 3 |
| Total formula weight | 22976.96 |
| Authors | Prabu-Jeyabalan, M.,Nalivaika, E.A.,Schiffer, C.A. (deposition date: 2006-01-11, release date: 2006-09-05, Last modification date: 2023-08-30) |
| Primary citation | Prabu-Jeyabalan, M.,Nalivaika, E.A.,Romano, K.,Schiffer, C.A. Mechanism of substrate recognition by drug-resistant human immunodeficiency virus type 1 protease variants revealed by a novel structural intermediate. J.Virol., 80:3607-3616, 2006 Cited by PubMed: 16537628DOI: 10.1128/JVI.80.7.3607-3616.2006 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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