2FNB

NMR STRUCTURE OF THE FIBRONECTIN ED-B DOMAIN, NMR, 20 STRUCTURES

2FNB の概要

• エントリーDOI: 10.2210/pdb2fnb/pdb
• 分子名称: PROTEIN (FIBRONECTIN) (1 entity in total)
• 機能のキーワード: ed-b, fibronectin, typeiii domain, angiogenesis, protein binding
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted, extracellular space, extracellular matrix: P02751
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 10148.23

構造登録者

Fattorusso, R.,Pellecchia, M.,Viti, F.,Neri, P.,Neri, D.,Wuthrich, K. (登録日: 1998-12-16, 公開日: 1998-12-23, 最終更新日: 2024-05-01)

主引用文献

Fattorusso, R.,Pellecchia, M.,Viti, F.,Neri, P.,Neri, D.,Wuthrich, K.
NMR structure of the human oncofoetal fibronectin ED-B domain, a specific marker for angiogenesis.
Structure Fold.Des., 7:381-390, 1999

PubMed Abstract: The process of angiogenesis (i.e. the formation of new blood vessels from pre-existing ones) is fundamental to physiological processes such as reproduction, development and repair, as well as to pathological conditions such as tumor progression, rheumathoid arthritis and ocular disorders. The oncofoetal ED-B domain, a specific marker of angiogenesis, consists of 91 amino acid residues that are inserted by alternative splicing into the fibronectin (FN) molecule.

PubMed: 10196121
DOI: 10.1016/S0969-2126(99)80051-3

実験手法

SOLUTION NMR