2FMZ

Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII and XIV with L- and D- phenylalanine, structure with D-Phenylalanine.

2FMZ の概要

• エントリーDOI: 10.2210/pdb2fmz/pdb
• 関連するPDBエントリー: 2FMG
• 分子名称: Carbonic anhydrase 2, ZINC ION, MERCURY (II) ION, ... (5 entities in total)
• 機能のキーワード: carbonic anhydrase, activators, lyase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29720.25

構造登録者

Temperini, C.,Scozzafava, A.,Vullo, D.,Supuran, C.T. (登録日: 2006-01-10, 公開日: 2006-05-23, 最終更新日: 2024-02-14)

• 主引用文献: Temperini, C.,Scozzafava, A.,Vullo, D.,Supuran, C.T.; Carbonic Anhydrase Activators. Activation of Isoforms I, II, IV, VA, VII, and XIV with l- and d-Phenylalanine and Crystallographic Analysis of Their Adducts with Isozyme II: Stereospecific Recognition within the Active Site of an Enzyme and Its Consequences for the Drug Design.; J.Med.Chem., 49:3019-3027, 2006; PubMed: 16686544; DOI: 10.1021/jm0603320

実験手法

X-RAY DIFFRACTION (1.6 Å)