2FME
Crystal structure of the mitotic kinesin eg5 (ksp) in complex with mg-adp and (r)-4-(3-hydroxyphenyl)-n,n,7,8-tetramethyl-3,4-dihydroisoquinoline-2(1h)-carboxamide
Summary for 2FME
Entry DOI | 10.2210/pdb2fme/pdb |
Descriptor | Kinesin-like protein KIF11, MAGNESIUM ION, (4R)-4-(3-HYDROXYPHENYL)-N,N,7,8-TETRAMETHYL-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDE, ... (5 entities in total) |
Functional Keywords | eg5 ksp mg-adp complex inhibitor, cell cycle |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P52732 |
Total number of polymer chains | 2 |
Total formula weight | 83663.01 |
Authors | Sheriff, S. (deposition date: 2006-01-09, release date: 2006-04-18, Last modification date: 2024-04-03) |
Primary citation | Tarby, C.M.,Kaltenbach III, R.F.,Huynh, T.,Pudzianowski, A.,Shen, H.,Ortega-Nanos, M.,Sheriff, S.,Newitt, J.A.,McDonnell, P.A.,Burford, N.,Fairchild, C.R.,Vaccaro, W.,Chen, Z.,Borzilleri, R.M.,Naglich, J.,Lombardo, L.J.,Gottardis, M.,Trainor, G.L.,Roussell, D.L. Inhibitors of human mitotic kinesin Eg5: Characterization of the 4-phenyl-tetrahydroisoquinoline lead series Bioorg.Med.Chem.Lett., 16:2095-2100, 2006 Cited by PubMed: 16458511DOI: 10.1016/j.bmcl.2006.01.056 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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