2FLB

Discovery of a Novel Hydroxy Pyrazole Based Factor IXa Inhibitor

Summary for 2FLB

• Entry DOI: 10.2210/pdb2flb/pdb
• Related: 1o5d
• Descriptor: Coagulation factor VII, Tissue factor, 2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE, ... (5 entities in total)
• Functional Keywords: active site-directed, short hydrogen bond-mediated, pyrazole-based inhibitor, hydrolase-blood clotting complex, hydrolase/blood clotting
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P08709 P08709; Isoform 1: Membrane ; Single-pass type I membrane protein . Isoform 2: Secreted : P13726
• Total number of polymer chains: 3
• Total formula weight: 70208.00

Authors

Katz, B.A. (deposition date: 2006-01-05, release date: 2006-04-04, Last modification date: 2017-10-11)

• Primary citation: Vijaykumar, D.,Sprengeler, P.A.,Shaghafi, M.,Spencer, J.R.,Katz, B.A.,Yu, C.,Rai, R.,Young, W.B.,Schultz, B.,Janc, J.; Discovery of novel hydroxy pyrazole based factor IXa inhibitor.; Bioorg.Med.Chem.Lett., 16:2796-2799, 2006; PubMed: 16487703; DOI: 10.1016/j.bmcl.2006.01.123

Experimental method

X-RAY DIFFRACTION (1.95 Å)