2FLB

Discovery of a Novel Hydroxy Pyrazole Based Factor IXa Inhibitor

2FLB の概要

• エントリーDOI: 10.2210/pdb2flb/pdb
• 関連するPDBエントリー: 1o5d
• 分子名称: Coagulation factor VII, Tissue factor, 2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE, ... (5 entities in total)
• 機能のキーワード: active site-directed, short hydrogen bond-mediated, pyrazole-based inhibitor, hydrolase-blood clotting complex, hydrolase/blood clotting
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P08709 P08709; Isoform 1: Membrane ; Single-pass type I membrane protein . Isoform 2: Secreted : P13726
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 70208.00

構造登録者

Katz, B.A. (登録日: 2006-01-05, 公開日: 2006-04-04, 最終更新日: 2024-11-13)

主引用文献

Vijaykumar, D.,Sprengeler, P.A.,Shaghafi, M.,Spencer, J.R.,Katz, B.A.,Yu, C.,Rai, R.,Young, W.B.,Schultz, B.,Janc, J.
Discovery of novel hydroxy pyrazole based factor IXa inhibitor.
Bioorg.Med.Chem.Lett., 16:2796-2799, 2006

PubMed Abstract: Synthesis and biological data of a novel selective and efficacious factor IXa inhibitor are described along with its crystal structure in factor VIIa.

PubMed: 16487703
DOI: 10.1016/j.bmcl.2006.01.123

実験手法

X-RAY DIFFRACTION (1.95 Å)