2FK6

Crystal Structure of RNAse Z/tRNA(Thr) complex

2FK6 の概要

• エントリーDOI: 10.2210/pdb2fk6/pdb
• 関連するPDBエントリー: 1WW1 1Y44
• 分子名称: TRNA(THR), RIBONUCLEASE Z, ZINC ION, ... (6 entities in total)
• 機能のキーワード: protein-trna complex; zinc-dependent metal hydrolase; trna maturase, hydrolase-rna complex, hydrolase/rna
• 由来する生物種: Bacillus subtilis; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 61440.45

構造登録者

Li de la Sierra-Gallay, I.,Mathy, N.,Pellegrini, O.,Condon, C. (登録日: 2006-01-04, 公開日: 2006-03-21, 最終更新日: 2023-08-30)

主引用文献

Li de la Sierra-Gallay, I.,Mathy, N.,Pellegrini, O.,Condon, C.
Structure of the ubiquitous 3' processing enzyme RNase Z bound to transfer RNA.
Nat.Struct.Mol.Biol., 13:376-377, 2006

PubMed Abstract: The highly conserved ribonuclease RNase Z catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors. Here we present the structure of the complex between Bacillus subtilis RNase Z and tRNA(Thr), the first structure of a ribonucleolytic processing enzyme bound to tRNA. Binding of tRNA to RNase Z causes conformational changes in both partners to promote reorganization of the catalytic site and tRNA cleavage.

PubMed: 16518398
DOI: 10.1038/nsmb1066

実験手法

X-RAY DIFFRACTION (2.9 Å)