2FK0

Crystal Structure of a H5N1 influenza virus hemagglutinin.

2FK0 の概要

• エントリーDOI: 10.2210/pdb2fk0/pdb
• 分子名称: hemagglutinin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: glycoprotein, membrane-fusion precursor, viral protein
• 由来する生物種: Influenza A virus (A/Viet Nam/1203/2004(H5N1)); 詳細
• タンパク質・核酸の鎖数: 18
• 化学式量合計: 536738.95

構造登録者

Stevens, J.,Wilson, I.A. (登録日: 2006-01-03, 公開日: 2006-05-02, 最終更新日: 2024-11-20)

主引用文献

Stevens, J.,Blixt, O.,Tumpey, T.M.,Taubenberger, J.K.,Paulson, J.C.,Wilson, I.A.
Structure and Receptor Specificity of the Hemagglutinin from an H5N1 Influenza Virus.
Science, 312:404-410, 2006

PubMed Abstract: The hemagglutinin (HA) structure at 2.9 angstrom resolution, from a highly pathogenic Vietnamese H5N1 influenza virus, is more related to the 1918 and other human H1 HAs than to a 1997 duck H5 HA. Glycan microarray analysis of this Viet04 HA reveals an avian alpha2-3 sialic acid receptor binding preference. Introduction of mutations that can convert H1 serotype HAs to human alpha2-6 receptor specificity only enhanced or reduced affinity for avian-type receptors. However, mutations that can convert avian H2 and H3 HAs to human receptor specificity, when inserted onto the Viet04 H5 HA framework, permitted binding to a natural human alpha2-6 glycan, which suggests a path for this H5N1 virus to gain a foothold in the human population.

PubMed: 16543414
DOI: 10.1126/science.1124513

実験手法

X-RAY DIFFRACTION (2.95 Å)