2FJP

Human dipeptidyl peptidase IV/CD26 in complex with an inhibitor

Summary for 2FJP

• Entry DOI: 10.2210/pdb2fjp/pdb
• Descriptor: Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: alpha/beta, beta-propeller, dimer, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 174949.10

Authors

Scapin, G.,Patel, S.B.,Becker, J.W. (deposition date: 2006-01-03, release date: 2006-07-04, Last modification date: 2023-08-30)

• Primary citation: Edmondson, S.D.,Mastracchio, A.,Mathvink, R.J.,He, J.,Harper, B.,Park, Y.J.,Beconi, M.,Di Salvo, J.,Eiermann, G.J.,He, H.,Leiting, B.,Leone, J.F.,Levorse, D.A.,Lyons, K.,Patel, R.A.,Patel, S.B.,Petrov, A.,Scapin, G.,Shang, J.,Roy, R.S.,Smith, A.,Wu, J.K.,Xu, S.,Zhu, B.,Thornberry, N.A.,Weber, A.E.; (2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]- pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.; J.Med.Chem., 49:3614-3627, 2006; PubMed: 16759103; DOI: 10.1021/jm060015t

Experimental method

X-RAY DIFFRACTION (2.4 Å)