2FIL

Crystal Structure Analysis of the A-DNA Decamer GCGT-2'OMeA-faT-ACGC, with Incorporated 2'-O-Methylated-Adenosine (2'OMeA) and 2'-Fluoroarabino-Thymidine (faT)

Summary for 2FIL

• Entry DOI: 10.2210/pdb2fil/pdb
• Related: 2FIH 2FII 2FIJ
• Descriptor: 5'-D(*GP*CP*GP*TP*(A2M)P*(TAF)P*AP*CP*GP*C)-3', COBALT HEXAMMINE(III) (3 entities in total)
• Functional Keywords: 2'-fluoroarabino acid, sugar modifications, a-form dna, dna
• Total number of polymer chains: 4
• Total formula weight: 13499.90

Authors

Egli, M.,Li, F. (deposition date: 2005-12-29, release date: 2006-05-23, Last modification date: 2023-08-30)

• Primary citation: Li, F.,Sarkhel, S.,Wilds, C.J.,Wawrzak, Z.,Prakash, T.P.,Manoharan, M.,Egli, M.; 2'-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase H.; Biochemistry, 45:4141-4152, 2006; PubMed: 16566588; DOI: 10.1021/bi052322r

Experimental method

X-RAY DIFFRACTION (1.69 Å)