2FHY

Structure of human liver FPBase complexed with a novel benzoxazole as allosteric inhibitor

2FHY の概要

• エントリーDOI: 10.2210/pdb2fhy/pdb
• 関連するPDBエントリー: 2FIE 2FIX
• 分子名称: Fructose-1,6-bisphosphatase 1, MAGNESIUM ION, 2,5-DICHLORO-N-(5-CHLORO-1,3-BENZOXAZOL-2-YL)BENZENESULFONAMIDE (3 entities in total)
• 機能のキーワード: allosteric inhibitors human fbpase, benzoxazole, intersubunit allosteric inhibition of human fpbase, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 165587.29

構造登録者

Abad-Zapatero, C. (登録日: 2005-12-27, 公開日: 2006-02-21, 最終更新日: 2024-02-14)

主引用文献

von Geldern, T.W.,Lai, C.,Gum, R.J.,Daly, M.,Sun, C.,Fry, E.H.,Abad-Zapatero, C.
Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode.
Bioorg.Med.Chem.Lett., 16:1811-1815, 2006

PubMed Abstract: We have identified benzoxazole benzenesulfonamide 1 as a novel allosteric inhibitor of fructose-1,6-bisphosphatase (FBPase-1). X-ray crystallographic and biological studies of 1 indicate a distinct binding mode that recapitulates features of several previously reported FBPase-1 inhibitor classes.

PubMed: 16442285
DOI: 10.1016/j.bmcl.2006.01.015

実験手法

X-RAY DIFFRACTION (2.95 Å)