2FHI

SUBSTRATE ANALOG (IB2) COMPLEX WITH THE HIS 96 ASN SUBSTITUTION OF THE FRAGILE HISTIDINE TRIAD PROTEIN, FHIT

2FHI の概要

• エントリーDOI: 10.2210/pdb2fhi/pdb
• 分子名称: FRAGILE HISTIDINE TRIAD PROTEIN, P1-P2-METHYLENE-P3-THIO-DIADENOSINE TRIPHOSPHATE (3 entities in total)
• 機能のキーワード: nucleotide-binding protein, cancer, diadenosine triphosphate hydrolase, active site substitution, histidine triad, tumor suppressor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P49789
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17632.66

構造登録者

Pace, H.C.,Garrison, P.N.,Robinson, A.K.,Barnes, L.D.,Draganescu, A.,Rosler, A.,Blackburn, G.M.,Siprashvili, Z.,Croce, C.M.,Heubner, K.,Brenner, C. (登録日: 1998-04-01, 公開日: 1998-06-17, 最終更新日: 2024-05-29)

• 主引用文献: Pace, H.C.,Garrison, P.N.,Robinson, A.K.,Barnes, L.D.,Draganescu, A.,Rosler, A.,Blackburn, G.M.,Siprashvili, Z.,Croce, C.M.,Huebner, K.,Brenner, C.; Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit.; Proc.Natl.Acad.Sci.USA, 95:5484-5489, 1998; PubMed: 9576908; DOI: 10.1073/pnas.95.10.5484

実験手法

X-RAY DIFFRACTION (2.6 Å)