Crystal Structure of Mycobacterium Tuberculosis Proteasome in complex with a peptidyl boronate inhibitor MLN-273

Summary for 2FHH

Descriptor20S proteasome, alpha and beta subunits, proteasome, beta subunit, (1R)-3-METHYL-1-{[N-(MORPHOLIN-4-YLCARBONYL)-3-(1-NAPHTHYL)-D-ALANYL]AMINO}BUTYLBORONIC ACID, ... (4 entities in total)
Functional Keywordsmulti-subunit protein assembly, inhibitor-complex, hydrolase
Biological sourceMycobacterium tuberculosis
Total number of polymer chains28
Total molecular weight740808.45
Li, H. (deposition date: 2005-12-23, release date: 2006-02-28, Last modification date: 2011-07-13)
Primary citation
Hu, G.,Lin, G.,Wang, M.,Dick, L.,Xu, R.M.,Nathan, C.,Li, H.
Structure of the Mycobacterium tuberculosis proteasome and mechanism of inhibition by a peptidyl boronate.
Mol.Microbiol., 59:1417-1428, 2006
PubMed: 16468986 (PDB entries with the same primary citation)
DOI: 10.1111/j.1365-2958.2005.05036.x
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.229171.5%13.2%11.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution