2FHH

Crystal Structure of Mycobacterium Tuberculosis Proteasome in complex with a peptidyl boronate inhibitor MLN-273

Summary for 2FHH

• Entry DOI: 10.2210/pdb2fhh/pdb
• Related: 2FHG
• Descriptor: 20S proteasome, alpha and beta subunits, proteasome, beta subunit, (1R)-3-METHYL-1-{[N-(MORPHOLIN-4-YLCARBONYL)-3-(1-NAPHTHYL)-D-ALANYL]AMINO}BUTYLBORONIC ACID, ... (4 entities in total)
• Functional Keywords: multi-subunit protein assembly, inhibitor-complex, hydrolase
• Biological source: Mycobacterium tuberculosis; More
• Total number of polymer chains: 28
• Total formula weight: 740808.45

Authors

Li, H. (deposition date: 2005-12-23, release date: 2006-02-28, Last modification date: 2023-08-30)

• Primary citation: Hu, G.,Lin, G.,Wang, M.,Dick, L.,Xu, R.M.,Nathan, C.,Li, H.; Structure of the Mycobacterium tuberculosis proteasome and mechanism of inhibition by a peptidyl boronate.; Mol.Microbiol., 59:1417-1428, 2006; PubMed: 16468986; DOI: 10.1111/j.1365-2958.2005.05036.x

Experimental method

X-RAY DIFFRACTION (2.99 Å)