2FDW

Crystal Structure Of Human Microsomal P450 2A6 with the inhibitor (5-(Pyridin-3-yl)furan-2-yl)methanamine bound

2FDW の概要

• エントリーDOI: 10.2210/pdb2fdw/pdb
• 関連するPDBエントリー: 1Z10 1Z11 2FDU 2FDV 2FDY
• 分子名称: Cytochrome P450 2A6, PROTOPORPHYRIN IX CONTAINING FE, (5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE, ... (4 entities in total)
• 機能のキーワード: cyp2a6, p450 2a6, p450, monooxygenase, drug metabolizing enzyme, coumarin 7-hydroxylase, nicotine oxidase, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endoplasmic reticulum membrane; Peripheral membrane protein: P11509
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 221849.29

構造登録者

Yano, J.K.,Stout, C.D.,Johnson, E.F. (登録日: 2005-12-14, 公開日: 2006-11-28, 最終更新日: 2023-08-30)

• 主引用文献: Yano, J.K.,Denton, T.T.,Cerny, M.A.,Zhang, X.,Johnson, E.F.,Cashman, J.R.; Synthetic Inhibitors of Cytochrome P-450 2A6: Inhibitory Activity, Difference Spectra, Mechanism of Inhibition, and Protein Cocrystallization.; J.Med.Chem., 49:6987-7001, 2006; PubMed: 17125252; DOI: 10.1021/jm060519r

実験手法

X-RAY DIFFRACTION (2.05 Å)