Summary for 2FDP
| Descriptor | Beta-secretase 1, N1-((2S,3S,5R)-3-AMINO-6-(4-FLUOROPHENYLAMINO)-5-METHYL-6-OXO-1-PHENYLHEXAN-2-YL)-N3,N3-DIPROPYLISOPHTHALAMIDE (3 entities in total) |
|---|---|
| Functional Keywords | aspartyl protease, bace, hydrolase |
| Biological source | Homo sapiens (human) |
| Cellular location | Membrane; Single-pass type I membrane protein P56817 |
| Total number of polymer chains | 3 |
| Total molecular weight | 131449.37 |
| Authors | Yang, W.,Lu, W.,Lu, Y.,Zhong, M.,Sun, J.,Thomas, A.E.,Wilkinson, J.M.,Fucini, R.V.,Lam, M.,Randal, M.,Shi, X.P.,Jacobs, J.W.,McDowell, R.S.,Gordon, E.M.,Ballinger, M.D. (deposition date: 2005-12-14, release date: 2006-01-24, Last modification date: 2011-07-13) |
| Primary citation | Yang, W.,Lu, W.,Lu, Y.,Zhong, M.,Sun, J.,Thomas, A.E.,Wilkinson, J.M.,Fucini, R.V.,Lam, M.,Randal, M.,Shi, X.P.,Jacobs, J.W.,McDowell, R.S.,Gordon, E.M.,Ballinger, M.D. Aminoethylenes: a tetrahedral intermediate isostere yielding potent inhibitors of the aspartyl protease BACE-1. J.Med.Chem., 49:839-842, 2006 PubMed: 16451048 (PDB entries with the same primary citation) DOI: 10.1021/jm0509142  Import into Mendeley |
| Experimental method | X-RAY DIFFRACTION (2.5 Å) |
| NMR Information |
