2FDA

Crystal Structure of the Catalytic Domain of Human Coagulation Factor XIa in Complex with alpha-Ketothiazole Arginine Derived Ligand

Summary for 2FDA

Entry DOI	10.2210/pdb2fda/pdb
Related	1ZHR 1ZPB 1ZPC
Descriptor	Coagulation factor XI, BICARBONATE ION, SULFATE ION, ... (5 entities in total)
Functional Keywords	fxia, inhibitor, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Secreted: P03951
Total number of polymer chains	1
Total formula weight	27355.95
Authors	Jin, L.,Pandey, P.,Babine, R.E.,Weaver, D.T.,Abdel-Meguid, S.S.,Strickler, J.E. (deposition date: 2005-12-13, release date: 2006-04-18, Last modification date: 2023-08-30)
Primary citation	Deng, H.,Bannister, T.D.,Jin, L.,Babine, R.E.,Quinn, J.,Nagafuji, P.,Celatka, C.A.,Lin, J.,Lazarova, T.I.,Rynkiewicz, M.J.,Bibbins, F.,Pandey, P.,Gorga, J.,Meyers, H.V.,Abdel-Meguid, S.S.,Strickler, J.E. Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an alpha-ketothiazole arginine Bioorg.Med.Chem.Lett., 16:3049-3054, 2006 Cited by PubMed: 16524727 DOI: 10.1016/j.bmcl.2006.02.052 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation