2FB8

Structure of the B-Raf kinase domain bound to SB-590885

2FB8 の概要

• エントリーDOI: 10.2210/pdb2fb8/pdb
• 分子名称: B-Raf proto-oncogene serine/threonine-protein kinase, (1Z)-5-(2-{4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL}-5-PYRIDIN-4-YL-1H-IMIDAZOL-4-YL)INDAN-1-ONE OXIME (3 entities in total)
• 機能のキーワード: kinase domain, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus (By similarity): P15056
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 64734.83

構造登録者

Lougheed, J.C.,Lee, J.,Chau, D.C.,Stout, T.J. (登録日: 2005-12-08, 公開日: 2006-12-12, 最終更新日: 2024-02-14)

• 主引用文献: King, A.J.,Patrick, D.R.,Batorsky, R.S.,Ho, M.L.,Do, H.T.,Zhang, S.Y.,Kumar, R.,Rusnak, D.W.,Takle, A.K.,Wilson, D.M.,Hugger, E.,Wang, L.,Karreth, F.,Lougheed, J.C.,Lee, J.,Chau, D.,Stout, T.J.,May, E.W.,Rominger, C.M.,Schaber, M.D.,Luo, L.,Lakdawala, A.S.,Adams, J.L.,Contractor, R.G.,Smalley, K.S.,Herlyn, M.,Morrissey, M.M.,Tuveson, D.A.,Huang, P.S.; Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885.; Cancer Res., 66:11100-11105, 2006; PubMed: 17145850; DOI: 10.1158/0008-5472.CAN-06-2554

実験手法

X-RAY DIFFRACTION (2.9 Å)