2FAK

Crystal structure of Salinosporamide A in complex with the yeast 20S proteasome

2FAK の概要

• エントリーDOI: 10.2210/pdb2fak/pdb
• 関連するPDBエントリー: 1IRU 1RYP
• 分子名称: Proteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (16 entities in total)
• 機能のキーワード: proteasome, ubiquitin, drug design, inhibitor, protease, hydrolase
• 由来する生物種: Saccharomyces cerevisiae (baker's yeast); 詳細
• 細胞内の位置: Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
• タンパク質・核酸の鎖数: 28
• 化学式量合計: 705882.23

構造登録者

Groll, M.,Potts, B.C. (登録日: 2005-12-07, 公開日: 2006-04-18, 最終更新日: 2023-05-31)

• 主引用文献: Groll, M.,Huber, R.,Potts, B.C.; Crystal Structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in Complex with the 20S Proteasome Reveal Important Consequences of beta-Lactone Ring Opening and a Mechanism for Irreversible Binding.; J.Am.Chem.Soc., 128:5136-5141, 2006; PubMed: 16608349; DOI: 10.1021/ja058320b

実験手法

X-RAY DIFFRACTION (2.8 Å)