2F9V

HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with P1 and P2 cyclopropylalannines

Summary for 2F9V

Entry DOI	10.2210/pdb2f9v/pdb
Related	1A1R 1JXP 1N1L 2A4G 2A4Q 2A4R
Descriptor	NS3 protease/helicase, polyprotein, ZINC ION, ... (5 entities in total)
Functional Keywords	hcv, hepatitis c protease, ns3 protease, ketoamide inhibitor, viral protein
Biological source	Hepatitis C virus More
Total number of polymer chains	4
Total formula weight	48200.27
Authors	Bogen, S.L.,Ruan, S.,Liu, R.,Agrawal, S.,Pichardo, J.,Prongay, A.,Baroudy, B.,Saksena, A.,Girijavallabhan, V.,Njoroge, F.G. (deposition date: 2005-12-06, release date: 2007-01-09, Last modification date: 2024-03-13)
Primary citation	Bogen, S.L.,Ruan, S.,Liu, R.,Agrawal, S.,Pichardo, J.,Prongay, A.,Baroudy, B.,Saksena, A.,Girijavallabhan, V.,Njoroge, F.G. Depeptidization efforts on P3-P2 a-ketoamide inhibitors of HCV NS3-4A serine protease: Effect on HCV replicon activity. Bioorg.Med.Chem.Lett., 16:1621-1627, 2006 Cited by PubMed: 16387495 DOI: 10.1016/j.bmcl.2005.12.013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation