2F9V

HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with P1 and P2 cyclopropylalannines

2F9V の概要

関連するPDBエントリー1A1R 1JXP 2A4G 2A4Q 2A4R 1N1L
分子名称NS3 protease/helicase, polyprotein, ZINC ION, ... (5 entities in total)
機能のキーワードhcv, hepatitis c protease, ns3 protease, ketoamide inhibitor, viral protein
由来する生物種Hepatitis C virus
詳細
ポリマー鎖数4
分子量合計48200.27
構造登録者
Bogen, S.L.,Ruan, S.,Liu, R.,Agrawal, S.,Pichardo, J.,Prongay, A.,Baroudy, B.,Saksena, A.,Girijavallabhan, V.,Njoroge, F.G. (登録日: 2005-12-06, 公開日: 2007-01-09, 最終更新日: 2011-07-13)
主引用文献
Bogen, S.L.,Ruan, S.,Liu, R.,Agrawal, S.,Pichardo, J.,Prongay, A.,Baroudy, B.,Saksena, A.,Girijavallabhan, V.,Njoroge, F.G.
Depeptidization efforts on P3-P2 a-ketoamide inhibitors of HCV NS3-4A serine protease: Effect on HCV replicon activity.
Bioorg.Med.Chem.Lett., 16:1621-1627, 2006
PubMed: 16387495 (主引用文献が同じPDBエントリー)
DOI: 10.1016/j.bmcl.2005.12.013
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.6 Å)
NMR情報
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.182110.5%8.3%1.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード