2F9B
Discovery of Novel Heterocyclic Factor VIIa Inhibitors
Summary for 2F9B
Entry DOI | 10.2210/pdb2f9b/pdb |
Related | 1O5D |
Descriptor | Coagulation factor VII, Tissue factor, {5-(5-AMINO-1H-PYRROLO[3,2-B]PYRIDIN-2-YL)-6-HYDROXY-3'-NITRO-BIPHENYL-3-YL]-ACETIC ACID, ... (5 entities in total) |
Functional Keywords | serine protease, short hydrogen bond, active site-directed inhibitor, hydrolase-blood clotting complex, hydrolase/blood clotting |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P08709 P08709 Isoform 1: Membrane ; Single-pass type I membrane protein . Isoform 2: Secreted : P13726 |
Total number of polymer chains | 3 |
Total formula weight | 70294.04 |
Authors | Rai, R.,Kolesnikov, A.,Sprengeler, P.A.,Torkelson, S.,Ton, T.,Katz, B.A.,Yu, C.,Hendrix, J.,Shrader, W.D.,Stephens, R.,Cabuslay, R.,Sanford, E.,Young, W.B. (deposition date: 2005-12-05, release date: 2006-02-28, Last modification date: 2023-08-30) |
Primary citation | Rai, R.,Kolesnikov, A.,Sprengeler, P.A.,Torkelson, S.,Ton, T.,Katz, B.A.,Yu, C.,Hendrix, J.,Shrader, W.D.,Stephens, R.,Cabuslay, R.,Sanford, E.,Young, W.B. Discovery of novel heterocyclic factor VIIa inhibitors. Bioorg.Med.Chem.Lett., 16:2270-2273, 2006 Cited by PubMed: 16460932DOI: 10.1016/j.bmcl.2006.01.017 PDB entries with the same primary citation |
Experimental method |
Structure validation
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