2F7E

PKA complexed with (S)-2-(1H-Indol-3-yl)-1-(5-isoquinolin-6-yl-pyridin-3-yloxymethyl-etylamine

Summary for 2F7E

• Entry DOI: 10.2210/pdb2f7e/pdb
• Related: 1YDR
• Descriptor: cAMP-dependent protein kinase, alpha-catalytic subunit, PKI inhibitory peptide, (1S)-2-(1H-INDOL-3-YL)-1-{[(5-ISOQUINOLIN-6-YLPYRIDIN-3-YL)OXY]METHYL}ETHYLAMINE, ... (4 entities in total)
• Functional Keywords: protein kinase a, akt inhibitors, transferase
• Biological source: Bos taurus (cattle)
• Cellular location: Cytoplasm: P00517
• Total number of polymer chains: 2
• Total formula weight: 43298.53

Authors

Stoll, V.S. (deposition date: 2005-11-30, release date: 2006-06-27, Last modification date: 2024-02-14)

• Primary citation: Li, Q.,Woods, K.W.,Thomas, S.,Zhu, G.D.,Packard, G.,Fisher, J.,Li, T.,Gong, J.,Dinges, J.,Song, X.,Abrams, J.,Luo, Y.,Johnson, E.F.,Shi, Y.,Liu, X.,Klinghofer, V.,Des Jong, R.,Oltersdorf, T.,Stoll, V.S.,Jakob, C.G.,Rosenberg, S.H.,Giranda, V.L.; Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer.; Bioorg.Med.Chem.Lett., 16:2000-2007, 2006; PubMed: 16413780; DOI: 10.1016/j.bmcl.2005.12.065

Experimental method

X-RAY DIFFRACTION (2 Å)