2F70

Protein tyrosine phosphatase 1B with sulfamic acid inhibitors

Summary for 2F70

• Entry DOI: 10.2210/pdb2f70/pdb
• Related: 2F6T 2F6V 2F6W 2F6Y 2F71 2F7Z
• Descriptor: Tyrosine-protein phosphatase, non-receptor type 1, MAGNESIUM ION, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: ptp1b, sulfamic acids, tetrahydroisoquinoline, phosphatase, tyrosine, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
• Total number of polymer chains: 1
• Total formula weight: 35316.15

Authors

Evdokimov, A.G.,Pokross, M.E.,Klopfenstein, S.R. (deposition date: 2005-11-29, release date: 2005-12-13, Last modification date: 2023-08-23)

Primary citation

Klopfenstein, S.R.,Evdokimov, A.G.,Colson, A.-O.,Fairweather, N.T.,Neuman, J.J.,Maier, M.B.,Gray, J.L.,Gerwe, G.S.,Stake, G.E.,Howard, B.W.,Farmer, J.A.,Pokross, M.E.,Downs, T.R.,Kasibhatla, B.,Peters, K.G.
1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors
Bioorg.Med.Chem.Lett., 16:1574-1578, 2006

PubMed Abstract: High-throughput screening of the P&GP corporate repository against several protein tyrosine phosphatases identified the sulfamic acid moiety as potential phosphotyrosine mimetic. Incorporation of the sulfamic acid onto a 1,2,3,4-tetrahydroisoquinoline scaffold provided a promising starting point for PTP1B inhibitor design.

PubMed: 16386905
DOI: 10.1016/j.bmcl.2005.12.051

Experimental method

X-RAY DIFFRACTION (2.12 Å)