2F54

Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity

2F54 の概要

• エントリーDOI: 10.2210/pdb2f54/pdb
• 関連するPDBエントリー: 2F53
• 分子名称: HLA class I histocompatibility antigen, Beta-2-microglobulin, Cancer/testis antigen 1B, ... (6 entities in total)
• 機能のキーワード: t-cell receptor, cdr2, phage display, wild type sequence, high affinity, ny-eso-1, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P01892; Secreted: P61769; Cytoplasm: P78358
• タンパク質・核酸の鎖数: 10
• 化学式量合計: 188117.00

構造登録者

Rizkallah, P.J.,Jakobsen, B.K.,Dunn, S.M.,Sami, M. (登録日: 2005-11-25, 公開日: 2006-04-25, 最終更新日: 2023-08-23)

• 主引用文献: Dunn, S.M.,Rizkallah, P.J.,Baston, E.,Mahon, T.,Cameron, B.,Moysey, R.,Gao, F.,Sami, M.,Boulter, J.,Li, Y.,Jakobsen, B.K.; Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity.; Protein Sci., 15:710-721, 2006; PubMed: 16600963; DOI: 10.1110/ps.051936406

実験手法

X-RAY DIFFRACTION (2.7 Å)