2F3N

Crystal Structure of the native Shank SAM domain.

Summary for 2F3N

• Entry DOI: 10.2210/pdb2f3n/pdb
• Descriptor: SH3 and multiple ankyrin repeat domains 3 (2 entities in total)
• Functional Keywords: postsynaptic density, sam domain, shank, scaffolding protein, structural protein
• Biological source: Rattus norvegicus (Norway rat)
• Cellular location: Cytoplasm: Q9JLU4
• Total number of polymer chains: 3
• Total formula weight: 27276.31

Authors

Baron, M.K.,Bowie, J.U.,Faham, S. (deposition date: 2005-11-22, release date: 2006-02-07, Last modification date: 2024-02-14)

Primary citation

Baron, M.K.,Boeckers, T.M.,Vaida, B.,Faham, S.,Gingery, M.,Sawaya, M.R.,Salyer, D.,Gundelfinger, E.D.,Bowie, J.U.
An architectural framework that may lie at the core of the postsynaptic density.
Science, 311:531-535, 2006

PubMed Abstract: The postsynaptic density (PSD) is a complex assembly of proteins associated with the postsynaptic membrane that organizes neurotransmitter receptors, signaling pathways, and regulatory elements within a cytoskeletal matrix. Here we show that the sterile alpha motif domain of rat Shank3/ProSAP2, a master scaffolding protein located deep within the PSD, can form large sheets composed of helical fibers stacked side by side. Zn2+, which is found in high concentrations in the PSD, binds tightly to Shank3 and may regulate assembly. Sheets of the Shank protein could form a platform for the construction of the PSD complex.

PubMed: 16439662
DOI: 10.1126/science.1118995

Experimental method

X-RAY DIFFRACTION (2.1 Å)