2F38

Crystal structure of prostaglandin F synathase containing bimatoprost

2F38 の概要

• エントリーDOI: 10.2210/pdb2f38/pdb
• 分子名称: Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (5Z)-7-{(1R,2R,3R,5S)-3,5-DIHYDROXY-2-[(1E,3S)-3-HYDROXY-5-PHENYLPENT-1-ENYL]CYCLOPENTYL}-N-ETHYLHEPT-5-ENAMIDE, ... (4 entities in total)
• 機能のキーワード: prostaglandin f synthase, akr1c3, pgf2alpha fromation, pgh2, bimatoprost, catalytic mechanism, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P42330
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38055.19

構造登録者

Komoto, J.,Yamada, T.,Watanabe, K.,Woodward, D.F.,Takusagawa, F. (登録日: 2005-11-18, 公開日: 2006-10-31, 最終更新日: 2023-08-23)

• 主引用文献: Komoto, J.,Yamada, T.,Watanabe, K.,Woodward, D.F.,Takusagawa, F.; Prostaglandin F2alpha formation from prostaglandin H2 by prostaglandin F synthase (PGFS): crystal structure of PGFS containing bimatoprost.; Biochemistry, 45:1987-1996, 2006; PubMed: 16475787; DOI: 10.1021/bi051861t

実験手法

X-RAY DIFFRACTION (2 Å)