2EU2

Human Carbonic Anhydrase II in complex with novel inhibitors

Summary for 2EU2

• Entry DOI: 10.2210/pdb2eu2/pdb
• Related: 2EU3
• Descriptor: Carbonic anhydrase 2, ZINC ION, (R)-1-AMINO-1-[5-(DIMETHYLAMINO)-1,3,4-THIADIAZOL-2-YL]METHANESULFONAMIDE, ... (4 entities in total)
• Functional Keywords: carbonic anhydrase ii proton transfer inhibitor, lyase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 29591.77

Authors

Fisher, S.Z.,Govindasamy, L.,Boyle, N.,Agbandje-McKenna, M.,Silverman, D.N.,Blackburn, G.M.,McKenna, R. (deposition date: 2005-10-28, release date: 2006-07-11, Last modification date: 2023-08-23)

• Primary citation: Fisher, S.Z.,Govindasamy, L.,Boyle, N.,Agbandje-McKenna, M.,Silverman, D.N.,Blackburn, G.M.,McKenna, R.; X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes.; Acta Crystallogr.,Sect.F, 62:618-622, 2006; PubMed: 16820676; DOI: 10.1107/S1744309106020446

Experimental method

X-RAY DIFFRACTION (1.15 Å)