2EI6

FACTOR XA IN COMPLEX WITH THE INHIBITOR (-)-cis-N1-[(5-Chloroindol-2-yl)carbonyl]-N2-[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2-cyclohexanediamine

2EI6 の概要

• エントリーDOI: 10.2210/pdb2ei6/pdb
• 関連するPDBエントリー: 1v3x 1wu1 2EI7 2EI8 2d1j
• 分子名称: Coagulation factor X, heavy chain, Coagulation factor X, light chain, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P00742 P00742
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32745.69

構造登録者

Suzuki, M. (登録日: 2007-03-12, 公開日: 2008-03-18, 最終更新日: 2023-10-25)

• 主引用文献: Nagata, T.,Yoshino, T.,Haginoya, N.,Yoshikawa, K.,Isobe, Y.,Furugohri, T.,Kanno, H.; Cycloalkanediamine derivatives as novel blood coagulation factor Xa inhibitors.; Bioorg.Med.Chem.Lett., 17:4683-4688, 2007; PubMed: 17555959; DOI: 10.1016/j.bmcl.2007.05.068

実験手法

X-RAY DIFFRACTION (2.3 Å)