2EF7

Crystal structure of ST2348, a hypothetical protein with CBS domains from Sulfolobus tokodaii strain7

2EF7 の概要

• エントリーDOI: 10.2210/pdb2ef7/pdb
• 分子名称: Hypothetical protein ST2348 (2 entities in total)
• 機能のキーワード: cbs-domain, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi, oxidoreductase
• 由来する生物種: Sulfolobus tokodaii
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 30293.00

構造登録者

Agari, Y.,Karthe, P.,Kumarevel, T.,Yokoyama, S.,Kuramitsu, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (登録日: 2007-02-21, 公開日: 2007-08-21, 最終更新日: 2024-11-13)

主引用文献

Ragunathan, P.,Kumarevel, T.,Agari, Y.,Shinkai, A.,Kuramitsu, S.,Yokoyama, S.,Ponnuraj, K.
Crystal structure of ST2348, a CBS domain protein, from hyperthermophilic archaeon Sulfolobus tokodaii
Biochem.Biophys.Res.Commun., 375:124-128, 2008

PubMed Abstract: The crystal structure of a hypothetical protein ST2348 (GI: 47118305) from the hyperthermophilic bacteria Sulfolobus tokodaii has been determined using X-ray crystallography. The protein consists of two CBS (cystathione beta synthase) domains, whose function has been analyzed and reported here. PSI-BLAST shows a conservation of this domain in about 100 proteins in various species. However, none of the close homologs of ST2348 have been functionally characterized so far. Structure and sequence comparison of ST2348 with human AMP-kinase gamma1 subunit and the CBS domain pair of bacterial IMP dehydrogenase is suggestive of its binding to AMP and ATP. A highly conserved residue Asp118, located in a negatively charged patch near the ligand binding cleft, could serve as a site for phosphorylation similar to that found in the chemotatic signal protein CheY and thereby ST2348 can function as a signal transduction molecule.

PubMed: 18691556
DOI: 10.1016/j.bbrc.2008.07.140

実験手法

X-RAY DIFFRACTION (2.1 Å)