2EB2

Crystal structure of mutated EGFR kinase domain (G719S)

2EB2 の概要

• エントリーDOI: 10.2210/pdb2eb2/pdb
• 関連するPDBエントリー: 2EB3 3UG1 3UG2 3VJN 3VJO
• 分子名称: Epidermal growth factor receptor (2 entities in total)
• 機能のキーワード: kinase, tyrosine-protein kinase, receptor, transferase, phosphorylation, atp-binding, disease mutation, transmembrane, cell cycle, ec 2.7.10.1, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38007.95

構造登録者

Yoshikawa, S.,Kukimoto-Niino, M.,Chen, L.,Liu, Z.J.,Wang, B.C.,Shirouzu, M.,Senba, K.,Yamamoto, T.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (登録日: 2007-02-06, 公開日: 2008-02-12, 最終更新日: 2023-10-25)

• 主引用文献: Yoshikawa, S.,Kukimoto-Niino, M.,Parker, L.,Handa, N.,Terada, T.,Fujimoto, T.,Terazawa, Y.,Wakiyama, M.,Sato, M.,Sano, S.,Kobayashi, T.,Tanaka, T.,Chen, L.,Liu, Z.J.,Wang, B.C.,Shirouzu, M.,Kawa, S.,Semba, K.,Yamamoto, T.,Yokoyama, S.; Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor; Oncogene, 2012; PubMed: 22349823; DOI: 10.1038/onc.2012.21

実験手法

X-RAY DIFFRACTION (2.5 Å)