2E6D

Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with fumarate

2E6D の概要

• エントリーDOI: 10.2210/pdb2e6d/pdb
• 関連するPDBエントリー: 2DJL 2DJX 2E68 2E6A 2E6F
• 分子名称: Dihydroorotate dehydrogenase, COBALT HEXAMMINE(III), FLAVIN MONONUCLEOTIDE, ... (6 entities in total)
• 機能のキーワード: chagas disease, pyrimidine biosynthesis, dihydroorotate dehydrogenase, fumarate reductase, energy metabolism, redox homeostasis, flavoprotein, oxidoreductase
• 由来する生物種: Trypanosoma cruzi
• 細胞内の位置: Cytoplasm (By similarity): Q4D3W2
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70163.28

構造登録者

Inaoka, D.K.,Shimizu, H.,Sakamoto, K.,Shiba, T.,Kurisu, G.,Nara, T.,Aoki, T.,Harada, S.,Kita, K. (登録日: 2006-12-26, 公開日: 2008-01-15, 最終更新日: 2023-11-15)

• 主引用文献: Inaoka, D.K.,Sakamoto, K.,Shimizu, H.,Shiba, T.,Kurisu, G.,Nara, T.,Aoki, T.,Kita, K.,Harada, S.; Structures of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products: atomic resolution insights into mechanisms of dihydroorotate oxidation and fumarate reduction; Biochemistry, 47:10881-10891, 2008; PubMed: 18808149; DOI: 10.1021/bi800413r

実験手法

X-RAY DIFFRACTION (1.94 Å)